Large granular lymphocyte leukaemia associated with systemic sclerosis
نویسندگان
چکیده
منابع مشابه
[Large granular lymphocytic leukaemia].
BACKGROUND Large granular lymphocytic leukaemia (LGL-leukaemia) is considered a rare disease. LGL-leukaemia is usually of the T-cell type, but a minority displays an NK-cell phenotype. Incidence and prevalence are unknown. MATERIAL AND METHODS We identified patients with LGL-leukaemia (with well-defined diagnostic criteria) diagnosed at Rikshospitalet University Hospital between 01.10.2001 an...
متن کاملLarge granular lymphocyte leukemia.
Clonal diseases of large granular lymphocytes (LGLs) represent a spectrum of clinically rare lymphoproliferative malignancies arising from either mature T-cell (CD3(+)) or natural killer (NK)-cell (CD3(-)) lineages. The clinical behavior of these disorders ranges from indolent to very aggressive. Patients with symptomatic indolent T-cell or NK-cell LGL leukemia are usually treated with immunosu...
متن کاملAssociation of pure red cell aplasia with T large granular lymphocyte leukaemia.
AIM To define the relation between T large granular lymphocyte (T-LGL) leukaemia and pure red cell aplasia in Chinese patients. METHODS Patients with T-LGL leukaemia were identified from a consecutive series of Chinese patients with chronic lymphoproliferative disorders. The diagnosis of T-LGL leukaemia was based on typical morphological and immunophenotypical features, and confirmed by the d...
متن کاملLeukaemia of natural killer cell large granular lymphocyte type with HLA-DR-CD16-CD56bright+ phenotype.
The case is reported of a 45 year old woman with the rare leukaemia of natural killer cell large granular lymphocyte (NK/ LGL) type. Cytometric analysis of leukaemic blasts showed that they were positive for CD2, CD38, and CD56 antigens but negative for a series of antigens including CD3, CD7, CD16, and HLA-DR. Rearrangements of the beta T cell receptor, and heavy and kappa immunoglobulin genes...
متن کاملSystemic sclerosis and chronic lymphocytic leukaemia.
The association between the CREST (calcinosis, Raynaud phenomena, oesophageal hypomotility, sclerodactyly and telangiectasia, variant of systemic sclerosis and chronic lymphocytic leukaemia is described in three patients. The present description raises the possibility that the association of chronic lymphocytic leukaemia and systemic sclerosis is non-random.
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2004
ISSN: 1460-2172
DOI: 10.1093/rheumatology/keh293